Five people, including two adults and three children, were killed Sunday afternoon when a Chevrolet Tahoe going eastbound on Interstate 10 plunged from an overpass onto FM 725 in Seguin.
The Seguin Police Department says the victims, an adult man, an adult woman and three children were all from the Houston area.
The crash happened just before 1 p.m. and police say the Tahoe was the only vehicle involved.
Authorities are waiting to notify next of kin before releasing the names of the victims.
The cause of the crash remains under investigation.
The roadway reopened at 6:03 p.m.